National Sleep Foundation

Chapter 4: Primary Hypersomnias

Etiology and Risk Factors

While the etiology of Kleine-Levin Syndrome is unknown, studies have shown that it may be precipitated by viral infections, head trauma, and alcohol consumption.65  A primary hypothalamic dysfunction and the HLA subtype DQB1*02 may be associated with the disease.66

References

  1. Dauvilliers Y, Mayer G, Lecendreux M, et al. Kleine-Levin syndrome: an autoimmune hypothesis based on clinical and genetic analyses. Neurology. 2002;59:1739-1745.
  2. Dauvilliers Y, Mayer G, Lecendreux M, et al. Kleine-Levin syndrome: an autoimmune hypothesis based on clinical and genetic analyses. Neurology. 2002;59:1739-1745.